Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fumonisin B1 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrosphingosine + myristoyl-CoA | Homo sapiens | - |
N-myristoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + palmitoyl-CoA | Homo sapiens | - |
N-palmitoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + palmitoyl-CoA | Homo sapiens | best substrate | N-palmitoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + stearoyl-CoA | Homo sapiens | - |
N-stearoyldihydrosphingosine + CoA | - |
? | |
additional information | Homo sapiens | CERS4 transfers C18 and C20 fatty acids | ? | - |
? | |
additional information | Homo sapiens | CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids | ? | - |
? | |
additional information | Homo sapiens | CERS6 transfers C14 and C16 fatty acids | ? | - |
? | |
sphingosine + eicosanoyl-CoA | Homo sapiens | - |
N-eicosanoylsphingosine + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6ZMG9 | - |
- |
Homo sapiens | Q8N5B7 | - |
- |
Homo sapiens | Q9HA82 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrosphingosine + myristoyl-CoA | - |
Homo sapiens | N-myristoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + palmitoyl-CoA | - |
Homo sapiens | N-palmitoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + palmitoyl-CoA | best substrate | Homo sapiens | N-palmitoyldihydrosphingosine + CoA | - |
? | |
dihydrosphingosine + stearoyl-CoA | - |
Homo sapiens | N-stearoyldihydrosphingosine + CoA | - |
? | |
additional information | CERS4 transfers C18 and C20 fatty acids | Homo sapiens | ? | - |
? | |
additional information | CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids | Homo sapiens | ? | - |
? | |
additional information | CERS6 transfers C14 and C16 fatty acids | Homo sapiens | ? | - |
? | |
additional information | CERS activity is assayed using LC-MS/MS for product quantification, crude extracts containing cell membranes are firstly prepared from tissues or cultured cells, reactions contain deuterated dihydrosphingosine (or sphingosine) and a fatty acid substrate linked to CoA (C16:0 to C24:0/24:1), detailed method descritpion and evaluation, overview | Homo sapiens | ? | - |
? | |
sphingosine + eicosanoyl-CoA | - |
Homo sapiens | N-eicosanoylsphingosine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase 4 | - |
Homo sapiens |
ceramide synthase 5 | - |
Homo sapiens |
ceramide synthase 6 | - |
Homo sapiens |
CerS4 | - |
Homo sapiens |
CerS5 | - |
Homo sapiens |
CerS6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ceramides are synthesized by ceramide synthases through the addition of a variable length fatty acid to the amine group of a sphingoid base. In mammalian cells, the sphingoid base used for de novo ceramide synthesis is usually the C18:0 lipid dihydrosphingosine. Ceramide synthesis is catalyzed by a family of six ceramide synthases (CERS1-6), each of which preferentially transfers fatty acids of different lengths to the amine group of dihydrosphingosine | Homo sapiens |